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Ophthalmic pathology in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation

2022 (3) CD009569

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1.2% placebo in SUSTAIN-1 Typical onset / first 4 to 8 weeks of titration, dose-dependent Median duration / most episodes resolve within 10 to 14 days at each dose step Top dietary strategy / small meals (200 to 300 kcal) every 3 to 4 hours Key soluble fiber sources / oats, peeled potatoes, white rice, ripe bananas Foods to limit / high-fat meals, sugar alcohols, raw cruciferous vegetables Hydration target / 1 to 1.5 L oral rehydration solution per day during active symptoms When to escalate / more than 6 loose stools daily, blood in stool, or signs of dehydration Dose adjustment / Novo Nordisk prescribing information allows 4-week dose-step delays Probiotic evidence / Lactobacillus rhamnosus GG shows modest benefit for drug-induced diarrhea Why Ozempic Causes Diarrhea Semaglutide is a GLP-1 receptor agonist that slows gastric emptying by 10% to 30%, but its effects on the lower gut are more nuanced